gotta ask if your following the "how-to" from github for wasteland reborn/loreout?
"Do note that you MUST use FULL (ALL DLC, except high-res textures) LATEST Steam version of Fallout 4 because we've said so. Not up for debates."
"After you have done everything above and have a clean Fallout 4 game folder, start the Launcher and let it do the initial graphics check. Do not worry about this part, as the installation will replace these graphics settings, then Start Fallout 4"
-these are just a few things i took from the how-to, its almost like you didnt fire up the game one time or i hope its that simple? if you dont have antivirus exclusions setup, give it a try.