When it wants you to do something involving an item, such as putting one into a workshop bench: do not shift+drag to put in a certain amount, put the entire stack in, or else it won't recognize it.
Sometimes it also doesn't recognize you acquiring certain items if it's already in your inventory.
Also apparently the old journey system used to lead you to The Dregs, the new one does not at all. And there's nothing to suggest you should even go in that location, the map is even created to steer you away from there.